14:00-15:00
Gathering and Registration
15:00-16:45
Session 1: Neuro-immunology of the Peripheral Nervous System
Chairpersons: Joab Chapman
15:00-15:30
Pipeline in CIDP therapy
Alon Abraham
15:30-15:45
RISK OF NEW ONSET MYASTHENIA GRAVIS FOLLOWING COVID19 INFECTION AND VACCINATION: A POPULATION-BASED CASE-CONTROL STUDY
Adi Wilf-Yarkoni
15:45-16:00
IMMUNE CHECKPOINT DOWNREGULATION AND NEGATIVE CORRELATION OF TIGIT EXPRESSION WITH ADL SCORES IN MYASTHENIA GRAVIS
Garrick Hoichman
16:00-16:15
BRONCHIECTASIS IN MYASTHENIA GRAVIS: A CLINICALLY RELEVANT COMORBIDITY DEFINING A HIGH-RISK TRIAD WITH THYMOMA
Ifat Vigiser
16:15-16:30
TEMPORAL DYNAMICS OF PERIPHERAL NERVE EXCITABILITY FOLLOWING COMPLETE FREUND’S ADJUVANT-INDUCED INFLAMMATION IN MICE
Shani Berkowitz
16:30-16:45
REAL-WORLD OUTCOMES OF EFGARTIGIMOD IN AChR-POSITIVE GENERALIZED MYASTHENIA GRAVIS: RESPONSE PATTERNS, PREDICTORS AND TREATMENT STRATEGIES
Lior Fuchs
16:45-17:15
Coffee Break, Poster Viewing & Professional Exhibition
17:15-19:00
Session 2: Aging and Neuroimmunology
Chairpersons: Dan Frenkel, Arnon Karni
17:15-17:45
White matter matters: A key player in brain aging
Tal Iram
17:45-18:15
Debate: To treat or not to treat after age 60
Daniel Golan (moderator), Tali Drori, Ifat Vigiser, Michael Osherov
18:15-18:30
EARLY NEURONAL-GLIAL REPROGRAMMING AND CELL CYCLE RE-ENTRY SHAPE THE ALZHEIMER’S DISEASE CASCADE
Gali Schwartz
18:30-18:45
HPG AXIS DYSREGULATION IN AGING IMPACTS BLOOD-BRAIN BARRIER INTEGRITY AND ALZHEIMER-LIKE DISEASE PATHOLOGY
Omri Kogman
18:45-19:00
CHARTING THE IMPACT OF GLYCEMIC STRESS ON CEREBROVASCULAR VULNERABILITY
Iftach Shaked
08:00-09:00
Registration
09:00-10:40
Session 3: B Cells and CNS Demyelinating Diseases
Chairpersons: Adi Vaknin, Keren Regev
*Sponsorship without involvement in content
09:00-09:40
B Cells and immune tolerance
Thomas Korn (Univ. Munich, Germany)
09:40-10:10
BTK inhibitors in neuro-immunology
Ron Milo
10:10-10:25
REDUCED TOLEROGENIC FACTOR sCD83 IN NMOSD AND RELAPSING MOGAD: A POTENTIAL NEW THERAPEUTIC PATHWAY
Ariel Rechtman
10:25-10:40
A PREDICTIVE MODEL FOR TRIPLE NEGATIVE OPTIC NEURITIS PATIENTS: IDENTIFYING THE SUBSET OF PATIENTS WITH FAVORABLE OUTCOMES
Ariel Rechtman
10:40-11:10
Coffee Break, Poster Viewing & Professional Exhibition
11:10-13:00
Session 4: Clinical Neuro-immunology
Chairpersons: Tali Drori
*Sponsorship without involvement in content
11:10-11:40
Debate: New diagnostic criteria for MS – pros and cons
Adi Wilf-Yarkoni (moderator), Alla Shifrin, Maya Garty Ofir
11:40-11:55
UNLOCKING THE MYSTERIES OF FIBROMYALGIA SYNDROME: EXPLORING EXTRACELLULAR VESICLES AS NEW PROMISING BIOMARKERS
Linoy Israel
11:55-12:10
BACILLUS CALMETTE-GUERIN IMPACT ON ALZHEIMER’S DISEASE, POSSIBLY VIA THE UNFOLDED PROTEIN RESPONSE
Benjamin Klein
12:10-12:25
ANTI LGI1 ENCEPHALITIS, BEYOND THE LIMBIC SYSTEM – PERSISTENT EXECUTIVE DYSFUNCTION IN LONG-TERM FOLLOW-UP
Avi Gadoth
12:25-12:40
THE IMPACT OF COGNITIVE BEHAVIORAL AND MINDFULNESS INTERVENTION ON GUT-IMMUNE-BRAIN INTERACTIONS IN CROHN`S DISEASE
Michal Grinberg
12:40-12:55
HEAVY METAL MAYHEM: IS CADMIUM ROCKING THE MS BOAT
Ayelet Armon Omer
13:00-14:00
Lunch
14:00-15:55
Session 5: CNS Repair
Chairpersons: Tal Burstyn-Cohen, Tamir Ben-Hur
14:00-14:40
Scar formation and CNS repair [via zoom]
Christian Goritz (Karolinska, Sweden)
14:40-15:10
Novel effectors in resolving inflammation and tissue repair
Amiram Ariel
15:10-15:25
TRIACK A NOVEL IRREVERSIBLE HIGH POTENCY THROMBIN PATHWAY MODULATOR IN EYE DROPS PENETRATES TO MURINE AND PIG RETINA
Shany Gofrit
15:25-15:40
MOLECULAR REGULATORS OF OLIGODENDROCYTE MATURATION AND REMYELINATION: FOCUS ON WWOX
Baraa Abu-Diab
15:40-15:55
MICROGLIA DEVELOPMENT, PHAGOCYTOSIS AND IMMUNE FUNCTIONS ARE REGULATED BY PROS1
Tal Burstyn-Cohen
15:55-16:30
Coffee Break, Poster Viewing & Professional Exhibition
16:30-17:45
Session 6: Guided Poster Walk with Cheese & Wine
Chair and Moderator: Avi Gadoth
NOVEL MOUSE MODEL FOR LATE-ONSET MULTIPLE SCLEROSIS
Tamar Shalet
MAPPING THE MS PRODROME: CLINICAL PATTERNS AND TIMING PRIOR TO DIAGNOSIS IN A POPULATION-BASED EHR STUDY FROM ISRAEL
Yarden Kleinberger
THE EFFECTS OF PHYTOCANNABINOIDS ON PROGRESSION OF THE ALS DISEASE AND NUEROINFLAMMATION
Sigal Fleisher-Berkovich
EVALUATING THE ROLE OF CANNABINOID ACIDS IN NEUROINFLAMMATION AND MULTIPLE SCLEROSIS
Nitsan Sharon
FUS TREATMENT FOR MS RELATED TREMOR
Alla Shifrin
ASTROCYTIC RESPONSES AND THEIR REGULATORS HAVE DIVERGENT ROLES IN AGEING AND ALZHEIMER`S DISEASE
Nadav Elan Eliash
POTENTIAL NEW THERAPEUTIC APPROACH FOR NEUROINFLAMMATION AND MULTIPLE SCLEROSIS: CANNABINOID ACIDS AS BLOOD BRAIN BARRIER MODULATORS
Taima Zeadnaa-Aldda
NEURO-IMMUNE ENGRAMS: LINKING TISSUE MEMORY AND BRAIN CIRCUITS IN SKIN INFLAMMATION
Margarita Sirotkin
EXPRESSION OF HUMAN P16 IN MOUSE CX3CR1-EXPRESSING CELLS INCREASES NEUROINFLAMMATION AND EXACERBATES COGNITIVE IMPAIRMENT IN 5XFAD MICE
Elisa Gozlan
IMMUNE-SUPPRESIVE ROLE OF CD83 PROTEIN IN SEIZURE REGULATION
Nikki Gordon
NEUROINFLAMMATION AND BLOOD–BRAIN BARRIER DYSFUNCTION IN WILLIAMS SYNDROME: AN EMERGING AVENUE FOR TREATMENT
Gal Wiener
08:00-09:00
ISNI Members Meeting
09:00-10:55
Session 7: Microglia and Neuro-degeneration
Chairpersons: Alon Monsonego, Eitan Okun
09:00-09:40
APOE4-TGFb signaling drives immune checkpoint pathways that restrain microglial response in Alzheimer’s disease
Oleg Butovsky (Harvard, USA)
09:40-10:10
Glial cells at the crossroads of Alzheimer’s and healthy brain aging
Naomi Habib
10:10-10:25
CHRONIC STRESS ATTENUATES CNS MYELOID CELL FUNCTION AND NEUROTOXICITY IN ALZHEIMER’S DISEASE
Yoel Shor
10:25-10:40
A HIGHLY PHAGOCYTIC ALZHEIMER’S DISEASE – ASSOCIATED MICROGLIAL POPULATION EXPRESSING TSG101 GENERATES INTRACELLULAR AMYLOID AGGREGATES
Marva Lachish
10:40-10:55
THE AUTISM-ASSOCIATED PROTEIN CHD8 REGULATES AUTISM-RELATED BEHAVIOR BY MODULATING MICROGLIAL NUMBER, TRANSCRIPTOME AND ACTIVITY
Evan Elliott
10:55-11:15
Coffee Break, Poster Viewing & Professional Exhibition
11:15-13:00
Session 8: Biomarkers and Diagnostics in Demyelinating Diseases
Chairpersons: Alla Shifrin, Efrat Shavit-Stein
*Sponsorship without involvement in content
11:15-11:45
Debate: New biomarkers in demyelinating diseases
Hadar Kolb and Panaiyota Petrou
11:45-12:00
APPLICATION OF THE 2024 MCDONALD CRITERIA IN THE INTERNATIONAL ACUTE OPTIC NEURITIS
Adi Wilf-Yarkoni
12:00-12:15
BRAIN ATROPHY IN NMOSD AND MOGAD: A META-ANALYSIS OF VOLUMETRIC AND DTI BIOMARKERS
Ariel Rechtman
12:15-12:30
NEUROFILAMENT LIGHT CHAIN MEASUREMENTS BY CENTAUR AND SIMOA SYSTEMS IN HUMAN AND MURINE SAMPLES
Tali Drori
12:30-12:45
SERUM CALPROTECTIN AS A BIOMARKER OF INFLAMMATORY ACTIVITY AND TREATMENT RESPONSE IN RELAPSING MULTIPLE SCLEROSIS: A PROSPECTIVE STUDY COMPARED TO NEUROFILAMENT LIGHT CHAIN
Ifat Vigiser
12:45-13:00
NEUROFILAMENT LIGHT CHAIN FROM SERUM CIRCULATING NEURONAL-DERIVED EXTRACELLULAR VESICLES UN PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS PATIENTS
Rina Ilona Zilkha-Falb
13:00-14:30
Lunch
