8:00-8:40 Registration and Breakfast
08:40-10:10 Session 1: Gut-Immune-Brain Interactions in Neuroinflammation
Chairs: Dan Frenkel, Yifat Vigiser
08:40-09:00 Asya Rolls – CNS mediated gut tolerance
09:00-09:20 Eran Blacher – The gut as a novel front of immune activation after stroke
09:20-09:40 Nissan Yissachar – Enteric Neuroimmunology
09:40-10:00 Amir Minerbi – The microbiome as a therapeutic target in chronic pain
10:00-10:10 Alon Zemer – SINGLE-NUCLEUS HYPOTHALAMUS RNA-SEQ UNCOVERS MICROGLIA SUBTYPES: POSSIBLE RELEVANCE TO OBESITY AND WEIGHT LOSS IN MID-AGE.
10:10-10:35 Coffee Break
10:35-11:40 Keynote Lectures
Chairs: Tamir Ben-Hur, Alon Monsonego
10:35-11:05 Michal Schwartz
11:05-11:40 Francisco Quintana
11:40-13:00 Session 2: Immune Aspects of Neuropsychiatry and Aging
Chairs: Alla Shifrin, Marc Helman
11:40-12:00 Alon Monsonego – Immune system aging, immune system aging underlying age-related disease susceptibility
12:00-12:15 Joab Chapman – Neuropsychiatric manifestations of systemic autoimmune disease
12:15-12:30 Keren Regev – Evidence based medicine on MS therapy in aging people
12:30-12:40 Hodaya Polonsky – THE ROLE OF THE BRAIN-SPLEEN CIRCUIT IN THE CONTROL OF SYMPTOM ONSET IN ALZHEIMER’S DISEASE
12:40-12:50 Marva Lachish – TSG101, A NOVEL MARKER OF HIGHLY PHAGOCYTIC, DISEASE-ASSOCIATED MICROGLIA IN THE ALZHEIMER`S DISEASE BRAIN
12:50-13:00 Dan Frenkel – METABOLIC CHANGES WITHIN ASTROCYTES AND THEIR LINK TO NEURODEGENERATION
13:00-14:00 Lunch
14:00-15:10 Session 3: Basic and Clinical Aspects of MS and Neuroinflammation
Chairs: Eyal Rosenberg, Maya Garti-Ophir
14:00-14:20 Ofira Einstein – Basic science and clinical data on physical exercise and MS
14:20-14:30 Ifat Vigiser – MIRNA SIGNATURE PROFILE AS A MARKER FOR DISEASE ACTIVITY IN MULTIPLE SCLEROSIS
14:30-14:40 Inbal Benhar – MULTICELLULAR ANALYSIS OF THE CNS INJURY RESPONSE REVEALS A COORDINATED INTERFERON PROGRAM
14:40-14:50 Tal Friedman-Korn – THYROID HORMONE DYSFUNCTION IN MOGAD AND OTHER DEMYELINATING DISEASES
14:50-15:00 Tal Ganz – TARGETING CNS MYELOID INFILTRATES PROVIDES NEUROPROTECTION IN A PROGRESSIVE MULTIPLE SCLEROSIS MODEL
15:00-15:10 Jacob Golenser – INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) SIGNALING PATHWAY PREVENTS CEREBRAL MALARIA (CM) IN A MOUSE MODEL
15:10-16:10 Poster Session 4: Guided Tour With Coffee
Chair and Moderator: Avi Gadoth
16:10 -16:50 Session 5: Immune Mediated Small Fiber and Autonomic Neuropathies
Chairs: Joab Chapman, Adi Vaknin
16:10-16:20 Yehonatan Sharabi – Autoimmune Autonomic Ganglionopathy: Pathophysiology, Diagnosis, and Treatment
16:20-16:30 Shani Berkowitz – THE COMPLEMENT C3A RECEPTOR IS EXPRESSED IN THE PARANODE OF THE SCIATIC NERVE AND MODULATES EXCITABILITY AND EXHAUSTION OF LARGE FIBERS IN MICE
16:30-16:40 Adi Wilf-Yarkoni – MACHINE LEARNING APPLICATION FOR MYASTHENIA GRAVIS REGISTRY IN ISRAELI HEALTH CARE SYSTEM
16:40-16:50 Lior Fuchs – REAL WORLD EXPERIENCE WITH EFGARTIGIMOD IN PATIENTS WITH MYASTHENIA GRAVIS
16:50-17:00 Coffee Break
17:00-18:00 Session 6: Emerging MS Therapies
Chairs: Adi Wilf-Yarkoni, Panaiota Petrou
17:00-17:20 Ariel Miller – Aging with MS
17:20-17:30 Hadas Hardoon – DIETARY GUIDELINES FOR MULTIPLE SCLEROSIS – ISRAEL DIETETIC ASSOCIATION POSITION PAPER
17:30-17:40 Ayal Rozenberg – UPREGULATION OF CCR5/CCR2 DURING IMMUNE CELL-ASSOCIATED NEUROTOXICITY SYNDROME FOLLOWING CAR-T CELL THERAPY
17:40-17:50 Ariel Rechtman – A PROTECTIVE EFFECT OF LOWER MHC-II EXPRESSION IN MOGAD
17:50-18:00 Hadar Kolb – INTRATHECAL METHOTREXATE TREATMENT FOR PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS RESULTS FROM A PHASE I STUDY AND OPEN LABEL EXPERIENCE
18:00-18:10 Closing Remarks
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